Sustainable chemistry I - Bewerkingsoverzicht

R0900076: /* 23 juni 2025 */

2026-07-07T09:06:52Z

23 juni 2025

← Oudere versie		Versie van 7 jul 2026 11:06
Regel 6:		Regel 6:

	==Examenvragen==		==Examenvragen==
	===23 juni ~~2025~~===		===29 juni 2026===
	#An excited PhD student made a molecule which he thinks has good activity as an anti-inflammatory agent. What possible problems do you see with the compound based on principles of the design of safe chemicals?		#An excited PhD student made a molecule which he thinks has good activity as an anti-inflammatory agent. What possible problems do you see with the compound based on principles of the design of safe chemicals? (compound contained an allylic alcohol and a terminal alkene)
	#a) why is assymetric formation of the enantiomerically pure compounds generally not used in industry? b) Explain the differences in synthetic approach in medicinal and commercial route for sertralin (slide with tetralone to sertralin)		#a) why is assymetric formation of the enantiomerically pure compounds generally not used in industry? b) Explain the differences in synthetic approach in medicinal and commercial route for sertralin (slide with tetralone to sertralin)
	#a)Why has lignin not been used a lot in the past as a feedstock for biobased materials? Why is this changing? b) which new technologies have helped this development?		#a)Why has lignin not been used a lot in the past as a feedstock for biobased materials? Why is this changing? b) which new technologies have helped this development?

R0900076: /* Examenvragen */

2026-07-07T09:06:00Z

Examenvragen

← Oudere versie		Versie van 7 jul 2026 11:06
Regel 6:		Regel 6:

	==Examenvragen==		==Examenvragen==
			===23 juni 2025===
			#An excited PhD student made a molecule which he thinks has good activity as an anti-inflammatory agent. What possible problems do you see with the compound based on principles of the design of safe chemicals?
			#a) why is assymetric formation of the enantiomerically pure compounds generally not used in industry? b) Explain the differences in synthetic approach in medicinal and commercial route for sertralin (slide with tetralone to sertralin)
			#a)Why has lignin not been used a lot in the past as a feedstock for biobased materials? Why is this changing? b) which new technologies have helped this development?

	===23 juni 2025===		===23 juni 2025===
	#Via which mechanisms is following molecule toxic. Suggest (minor) structural adjustments to mitigate its toxicity.		#Via which mechanisms is following molecule toxic. Suggest (minor) structural adjustments to mitigate its toxicity.

R0834942: /* 23 juni 2025 */

2025-07-02T09:41:21Z

23 juni 2025

← Oudere versie		Versie van 2 jul 2025 11:41
Regel 7:		Regel 7:
	==Examenvragen==		==Examenvragen==
	===23 juni 2025===		===23 juni 2025===
	#Via which mechanisms is following molecule toxic. Suggest (minor) structural adjustments to mitigate its toxicity.[[Bestand:Alpha-vinylbenzyl_alcohol_2.jpg]]		#Via which mechanisms is following molecule toxic. Suggest (minor) structural adjustments to mitigate its toxicity.
			[[Bestand:Alpha-vinylbenzyl_alcohol_2.jpg]]
	#Explain the differences in synthetic approach in medicinal and commercial route for sildenafil to achieve the bond indicated with the arrow. Explain why this is not straightforward and explain why this is (nevertheless) advantageous. (arrow indicates the C=N bond in med chem route just after assembly of A and B fragment).		#Explain the differences in synthetic approach in medicinal and commercial route for sildenafil to achieve the bond indicated with the arrow. Explain why this is not straightforward and explain why this is (nevertheless) advantageous. (arrow indicates the C=N bond in med chem route just after assembly of A and B fragment).
	#Why is cellulose such an interesting biobased material considering sustainability? In wich ionic liquids does it dissolve and why? Compare the viscose process of cellulose with the ionic liquid process in terms of sustainability.		#Why is cellulose such an interesting biobased material considering sustainability? In wich ionic liquids does it dissolve and why? Compare the viscose process of cellulose with the ionic liquid process in terms of sustainability.

R0834942: /* 23 juni 2025 */

2025-07-02T09:40:57Z

23 juni 2025

← Oudere versie		Versie van 2 jul 2025 11:40
Regel 7:		Regel 7:
	==Examenvragen==		==Examenvragen==
	===23 juni 2025===		===23 juni 2025===
	#Via which mechanisms is following molecule toxic. Suggest (minor) structural adjustments to mitigate its toxicity.		#Via which mechanisms is following molecule toxic. Suggest (minor) structural adjustments to mitigate its toxicity.[[Bestand:Alpha-vinylbenzyl_alcohol_2.jpg]]
	[[Bestand:Alpha-vinylbenzyl_alcohol_2.jpg]]
	#Explain the differences in synthetic approach in medicinal and commercial route for sildenafil to achieve the bond indicated with the arrow. Explain why this is not straightforward and explain why this is (nevertheless) advantageous. (arrow indicates the C=N bond in med chem route just after assembly of A and B fragment).		#Explain the differences in synthetic approach in medicinal and commercial route for sildenafil to achieve the bond indicated with the arrow. Explain why this is not straightforward and explain why this is (nevertheless) advantageous. (arrow indicates the C=N bond in med chem route just after assembly of A and B fragment).
	#Why is cellulose such an interesting biobased material considering sustainability? In wich ionic liquids does it dissolve and why? Compare the viscose process of cellulose with the ionic liquid process in terms of sustainability.		#Why is cellulose such an interesting biobased material considering sustainability? In wich ionic liquids does it dissolve and why? Compare the viscose process of cellulose with the ionic liquid process in terms of sustainability.

	===26 juni 2023===		===26 juni 2023===

R0846615 op 23 jun 2025 om 17:06

2025-06-23T17:06:12Z

← Oudere versie		Versie van 23 jun 2025 19:06
Regel 8:		Regel 8:
	===23 juni 2025===		===23 juni 2025===
	#Via which mechanisms is following molecule toxic. Suggest (minor) structural adjustments to mitigate its toxicity.		#Via which mechanisms is following molecule toxic. Suggest (minor) structural adjustments to mitigate its toxicity.
			[[Bestand:Alpha-vinylbenzyl_alcohol_2.jpg]]
	#Explain the differences in synthetic approach in medicinal and commercial route for sildenafil to achieve the bond indicated with the arrow. Explain why this is not straightforward and explain why this is (nevertheless) advantageous. (arrow indicates the C=N bond in med chem route just after assembly of A and B fragment).		#Explain the differences in synthetic approach in medicinal and commercial route for sildenafil to achieve the bond indicated with the arrow. Explain why this is not straightforward and explain why this is (nevertheless) advantageous. (arrow indicates the C=N bond in med chem route just after assembly of A and B fragment).
	#Why is cellulose such an interesting biobased material considering sustainability? In wich ionic liquids does it dissolve and why? Compare the viscose process of cellulose with the ionic liquid process in terms of sustainability.		#Why is cellulose such an interesting biobased material considering sustainability? In wich ionic liquids does it dissolve and why? Compare the viscose process of cellulose with the ionic liquid process in terms of sustainability.

R0846615 op 23 jun 2025 om 16:57

2025-06-23T16:57:58Z

← Oudere versie		Versie van 23 jun 2025 18:57
Regel 6:		Regel 6:

	==Examenvragen==		==Examenvragen==
			===23 juni 2025===
			#Via which mechanisms is following molecule toxic. Suggest (minor) structural adjustments to mitigate its toxicity.
			#Explain the differences in synthetic approach in medicinal and commercial route for sildenafil to achieve the bond indicated with the arrow. Explain why this is not straightforward and explain why this is (nevertheless) advantageous. (arrow indicates the C=N bond in med chem route just after assembly of A and B fragment).
			#Why is cellulose such an interesting biobased material considering sustainability? In wich ionic liquids does it dissolve and why? Compare the viscose process of cellulose with the ionic liquid process in terms of sustainability.

	===26 juni 2023===		===26 juni 2023===
	#An excited PhD student made a molecule which he thinks has good activity as an anti-inflammatory agent. What possible problems do you see with the compound based on the principles of the design of safe chemicals? Give minor structural modifications. - 7 punten		#An excited PhD student made a molecule which he thinks has good activity as an anti-inflammatory agent. What possible problems do you see with the compound based on the principles of the design of safe chemicals? Give minor structural modifications. - 7 punten

R0758874: /* Vakinformatie */

2024-06-24T10:47:46Z

Vakinformatie

← Oudere versie		Versie van 24 jun 2024 12:47
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	==Vakinformatie==		==Vakinformatie==
	Sustainable chemistry is een 3 studiepuntenvak dat gedoceerd wordt door 3 proffen. Hierdoor is er niet elke week les en verschuift het lesmoment soms omwille van de beschikbaarheid ban de gastlectoren. Het deel over ionic liquids, designer safer chemicals en bioprocesses & biodegradable materials wordt gegeven door Mario Smet. Daarnaast zijn er nog 2 delen die door gastlectoren worden gegeven. Eén deel wordt gegeven door Koen Van Aken en handelt over EcoScale en sustainable chemistry. Het laatste deel wordt gegeven door de Italiaan Luigi Vaccaro en gaat over concrete voorbeelden van duurzame syntheses in de medicinale chemie.		Sustainable chemistry is een 3 studiepuntenvak dat gedoceerd wordt door 3 proffen. Hierdoor is er niet elke week les en verschuift het lesmoment soms omwille van de beschikbaarheid ban de gastlectoren. Het deel over ionic liquids, designer safer chemicals en bioprocesses & biodegradable materials wordt gegeven door Mario Smet. Daarnaast zijn er nog 2 delen die door gastlectoren worden gegeven. Eén deel wordt gegeven door Koen Van Aken en handelt over EcoScale en sustainable chemistry. Het laatste deel wordt gegeven door de Italiaan Luigi Vaccaro en gaat over concrete voorbeelden van duurzame syntheses in de medicinale chemie.

			In het jaar 2023 kregen we voor het deel van Vaccaro (medicinale syntheses) een formularium met de syntheses in grote lijnen, maar geen uitleg erbij. De hele complexe molecules dus niet vanbuiten kennen maar wel de belangrijke groepen er op weten en met welke solventen enzo die reageren en omvormen in de komende stappen, en vooral waarom!

	==Examenvragen==		==Examenvragen==

TimDeBels: /* 26 juni 2023 */

2023-06-26T14:37:21Z

26 juni 2023

← Oudere versie		Versie van 26 jun 2023 16:37
Regel 5:		Regel 5:
	==Examenvragen==		==Examenvragen==
	===26 juni 2023===		===26 juni 2023===
	#An excited PhD student made a molecule which he thinks has good activity as an anti-inflammatory agent. What possible problems do you see with the compound based on the principles of the design of safe chemicals? - 7 punten		#An excited PhD student made a molecule which he thinks has good activity as an anti-inflammatory agent. What possible problems do you see with the compound based on the principles of the design of safe chemicals? Give minor structural modifications. - 7 punten
	[[Bestand:Moleculeexaam260623.png]]		[[Bestand:Moleculeexaam260623.png]]
	#Explain the differences in synthetic approach in medicinal and commercial route for sildenafil to achieve the bond indicated with the arrow. Explain why this is not straightforward and explain why this is (nevertheless) advantageous. (arrow indicates the C=N bond in med chem route just after assembly of A and B fragment) - 6 punten		#Explain the differences in synthetic approach in medicinal and commercial route for sildenafil to achieve the bond indicated with the arrow. Explain why this is not straightforward and explain why this is (nevertheless) advantageous. (arrow indicates the C=N bond in med chem route just after assembly of A and B fragment) - 6 punten

R0758874: /* Examenvragen */

2023-06-26T10:53:51Z

Examenvragen

← Oudere versie		Versie van 26 jun 2023 12:53
Regel 5:		Regel 5:
	==Examenvragen==		==Examenvragen==
	===26 juni 2023===		===26 juni 2023===
	#An excited PhD student made a molecule which he thinks has good activity as an anti-inflammatory agent. What possible problems do you see with the compound based on the principles of the design of safe chemicals? ~~(terminal alkene, halogen on ester, and this branched on a quaternary carbon with two identical phenyl rings (1,4 both))~~ - 7 punten		#An excited PhD student made a molecule which he thinks has good activity as an anti-inflammatory agent. What possible problems do you see with the compound based on the principles of the design of safe chemicals? - 7 punten
	[[Bestand:Moleculeexaam260623.png]]		[[Bestand:Moleculeexaam260623.png]]
	#Explain the differences in synthetic approach in medicinal and commercial route for sildenafil to achieve the bond indicated with the arrow. Explain why this is not straightforward and explain why this is (nevertheless) advantageous. (arrow indicates the C=N bond in med chem route just after assembly of A and B fragment) - 6 punten		#Explain the differences in synthetic approach in medicinal and commercial route for sildenafil to achieve the bond indicated with the arrow. Explain why this is not straightforward and explain why this is (nevertheless) advantageous. (arrow indicates the C=N bond in med chem route just after assembly of A and B fragment) - 6 punten

R0758874: /* 26 juni 2023 */

2023-06-26T10:53:02Z

26 juni 2023

← Oudere versie		Versie van 26 jun 2023 12:53
Regel 6:		Regel 6:
	===26 juni 2023===		===26 juni 2023===
	#An excited PhD student made a molecule which he thinks has good activity as an anti-inflammatory agent. What possible problems do you see with the compound based on the principles of the design of safe chemicals? (terminal alkene, halogen on ester, and this branched on a quaternary carbon with two identical phenyl rings (1,4 both)) - 7 punten		#An excited PhD student made a molecule which he thinks has good activity as an anti-inflammatory agent. What possible problems do you see with the compound based on the principles of the design of safe chemicals? (terminal alkene, halogen on ester, and this branched on a quaternary carbon with two identical phenyl rings (1,4 both)) - 7 punten
	[[Bestand:~~355984592 572594135075336 6098404187891884338 n~~.png]]		[[Bestand:Moleculeexaam260623.png]]
	#Explain the differences in synthetic approach in medicinal and commercial route for sildenafil to achieve the bond indicated with the arrow. Explain why this is not straightforward and explain why this is (nevertheless) advantageous. (arrow indicates the C=N bond in med chem route just after assembly of A and B fragment) - 6 punten		#Explain the differences in synthetic approach in medicinal and commercial route for sildenafil to achieve the bond indicated with the arrow. Explain why this is not straightforward and explain why this is (nevertheless) advantageous. (arrow indicates the C=N bond in med chem route just after assembly of A and B fragment) - 6 punten
	#Compare PE plastic bag with biomaterials derived from starch. Which one is more sustainable? Explain this with respect to the formation of this material (polymer), the use and the end-of-life of this material. Give pros and cons of each. - 7 punten		#Compare PE plastic bag with biomaterials derived from starch. Which one is more sustainable? Explain this with respect to the formation of this material (polymer), the use and the end-of-life of this material. Give pros and cons of each. - 7 punten